Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate | Zendy

Daniel Szczerba | Zendy; Davin Tan | Zendy; JeanLouis Do | Zendy; Hatem M. Titi | Zendy; Siham Mouhtadi | Zendy; Denis Chaumont | Zendy; M.C. Marco de Lucas | Zendy; Nicolas Geoffroy | Zendy; Michel Meyer | Zendy; Yoann Rousselin | Zendy; Jessica M. Hudspeth | Zendy; Valérie Schwanen | Zendy; Petra Spoerk-Erdely | Zendy; AnnChristin Dippel | Zendy; Oleh Ivashko | Zendy; Olof Gutowski | Zendy; Philipp Glaevecke | Zendy; Vasilii V. Bazhenov | Zendy; Mihails Arhangelskis | Zendy; Iván Halász | Zendy; Tomislav Friščić | Zendy; Simon A. J. Kimber | Zendy

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Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Author(s) -

Daniel Szczerba,

Davin Tan,

JeanLouis Do,

Hatem M. Titi,

Siham Mouhtadi,

Denis Chaumont,

M.C. Marco de Lucas,

Nicolas Geoffroy,

Michel Meyer,

Yoann Rousselin,

Jessica M. Hudspeth,

Valérie Schwanen,

Petra Spoerk-Erdely,

AnnChristin Dippel,

Oleh Ivashko,

Olof Gutowski,

Philipp Glaevecke,

Vasilii V. Bazhenov,

Mihails Arhangelskis,

Iván Halász,

Tomislav Friščić,

Simon A. J. Kimber

Publication year - 2021

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.1c07186

Subject(s) - chemistry , bismuth , solvolysis , cluster (spacecraft) , colloid , catalysis , hydrolysis , nanoparticle , crystallography , stereochemistry , nanotechnology , chemical physics , organic chemistry , materials science , computer science , programming language

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi 9 O 7 } and {Bi 38 O 44 }, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi 3+ displacements. This explains why such "magic-size" clusters can be both stable enough to crystallize and sufficiently labile for further growth.

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