Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids | Zendy

Jacob Davies | Zendy; Daniel Janßen-Müller | Zendy; Dmitry P. Zimin | Zendy; Craig S. Day | Zendy; Tomoyuki Yanagi | Zendy; Jonas Elfert | Zendy; Rubén Martı́n | Zendy

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Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids

Author(s) -

Jacob Davies,

Daniel Janßen-Müller,

Dmitry P. Zimin,

Craig S. Day,

Tomoyuki Yanagi,

Jonas Elfert,

Rubén Martı́n

Publication year - 2021

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.1c01916

Subject(s) - chemistry , carboxylation , regioselectivity , catalysis , peptidomimetic , amino acid , blueprint , combinatorial chemistry , organic chemistry , biochemistry , mechanical engineering , peptide , engineering

A Ni-catalyzed reductive carboxylation of N- substituted aziridines with CO 2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.

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