Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis | Zendy

Francis M. Mann | Zendy; Meimei Xu | Zendy; Xiaohong Chen | Zendy; D. Bruce Fulton | Zendy; David G. Russell | Zendy; Reuben J. Peters | Zendy

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Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis

Author(s) -

Francis M. Mann,

Meimei Xu,

Xiaohong Chen,

D. Bruce Fulton,

David G. Russell,

Reuben J. Peters

Publication year - 2009

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja9019287

Subject(s) - diterpene , mycobacterium tuberculosis , chemistry , tuberculosis , human pathogen , metabolite , pathogen , microbiology and biotechnology , bacteria , mycobacterium , stereochemistry , biochemistry , biology , medicine , genetics , pathology , gene

Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.

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