Manganous Phosphate Acts as a Superoxide Dismutase
Author(s) -
Kevin Barnese,
Edith B. Gralla,
Diane E. Cabelli,
Joan Selverstone Valentine
Publication year - 2008
Publication title -
journal of the american chemical society
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja710162n
Subject(s) - chemistry , superoxide dismutase , enzyme , superoxide , disproportionation , catalase , antioxidant , phosphate , inorganic phosphate , biochemistry , intracellular , radical , ion , aqueous solution , catalysis , organic chemistry
A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate is unique among those manganous salts studied in its ability to remove superoxide rapidly and catalytically from aqueous solution via a disproportionation mechanism that is entirely different from those of the SOD enzymes.
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