Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides | Zendy

Adam Noble | Zendy; Stefan J. McCarver | Zendy; David W. C. MacMillan | Zendy

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Merging Photoredox and Nickel Catalysis: Decarboxylative Cross-Coupling of Carboxylic Acids with Vinyl Halides

Author(s) -

Adam Noble,

Stefan J. McCarver,

David W. C. MacMillan

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja511913h

Subject(s) - chemistry , halide , alkyl , catalysis , decarboxylation , nickel , organic chemistry , photoredox catalysis , combinatorial chemistry , photocatalysis

Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild, operationally simple reaction conditions.

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