A Mononuclear Manganese(II) Complex Demonstrates a Strategy To Simultaneously Image and Treat Oxidative Stress | Zendy

Meng Yu | Zendy; Stephen L. Ambrose | Zendy; Zachary L. Whaley | Zendy; Sanjun Fan | Zendy; John D. Gorden | Zendy; Ronald J. Beyers | Zendy; Dean D. Schwartz | Zendy; Christian R. Goldsmith | Zendy

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A Mononuclear Manganese(II) Complex Demonstrates a Strategy To Simultaneously Image and Treat Oxidative Stress

Author(s) -

Meng Yu,

Stephen L. Ambrose,

Zachary L. Whaley,

Sanjun Fan,

John D. Gorden,

Ronald J. Beyers,

Dean D. Schwartz,

Christian R. Goldsmith

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja507034d

Subject(s) - chemistry , oxidative stress , manganese , ligand (biochemistry) , antioxidant , magnetic resonance imaging , nuclear magnetic resonance , biophysics , biochemistry , organic chemistry , receptor , medicine , physics , biology , radiology

A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.

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