Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates | Zendy

Anna Lee | Zendy; Ashkaan Younai | Zendy; Christopher K. Price | Zendy; Javier Izquierdo | Zendy; Rama K. Mishra | Zendy; Karl A. Scheidt | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

Author(s) -

Anna Lee,

Ashkaan Younai,

Christopher K. Price,

Javier Izquierdo,

Rama K. Mishra,

Karl A. Scheidt

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja505880r

Subject(s) - chemistry , enantioselective synthesis , annulation , in situ , catalysis , dual (grammatical number) , quinone , quinone methide , combinatorial chemistry , stereochemistry , organic chemistry , art , literature

A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research