Poly(oligonucleotide) | Zendy

Carrie R. James | Zendy; Anthony M. Rush | Zendy; Thomas Insley | Zendy; Lela Vuković | Zendy; Lisa Adamiak | Zendy; Petr Král | Zendy; Nathan C. Gianneschi | Zendy

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Poly(oligonucleotide)

Author(s) -

Carrie R. James,

Anthony M. Rush,

Thomas Insley,

Lela Vuković,

Lisa Adamiak,

Petr Král,

Nathan C. Gianneschi

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja503142s

Subject(s) - chemistry , peptide nucleic acid , romp , monomer , oligonucleotide , polymerization , amphiphile , copolymer , nucleic acid , polymer chemistry , polymer , metathesis , dna , organic chemistry , biochemistry

Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

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