Ligand-Enabled γ-C–H Olefination and Carbonylation: Construction of β-Quaternary Carbon Centers | Zendy

Suhua Li | Zendy; Gang Chen | Zendy; ChenGuo Feng | Zendy; Wei Gong | Zendy; JinQuan Yu | Zendy

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Ligand-Enabled γ-C–H Olefination and Carbonylation: Construction of β-Quaternary Carbon Centers

Author(s) -

Suhua Li,

Gang Chen,

ChenGuo Feng,

Wei Gong,

JinQuan Yu

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja501689j

Subject(s) - chemistry , carbonylation , amide , ligand (biochemistry) , quinoline , carbon fibers , quaternary carbon , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , carbon monoxide , catalysis , receptor , composite number , enantioselective synthesis , biochemistry , materials science , composite material

Monoselective γ-C-H olefination and carbonylation of aliphatic acids has been accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide directing group. The reaction provides a new route for constructing richly functionalized all-carbon quaternary carbon centers at the β-position of aliphatic acids.

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