Open AccessCross-Coupling of Remote meta-C–H Bonds Directed by a U-Shaped Template
Author(s) -
Li Wan,
Navid Dastbaravardeh,
Gang Li,
JinQuan Yu
Publication year - 2013
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja410760f
Subject(s) - chemistry , nitrile , ligand (biochemistry) , coupling (piping) , combinatorial chemistry , methylation , stereochemistry , organic chemistry , biochemistry , receptor , mechanical engineering , engineering , gene
meta-C-H arylation and methylation of 3-phenylpropanoic acid and phenolic derivatives were developed using an easily removable nitrile template. The combination of a weakly coordinating U-shaped template and mono-protected amino acid ligand was crucial for the cross-coupling of C-H bonds with organoborons.
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