Kinetic Trapping of Metastable Amino Acid Polymorphs | Zendy

Azhad U. Chowdhury | Zendy; Christopher M. Dettmar | Zendy; Shane Z. Sullivan | Zendy; Shijie Zhang | Zendy; Kevin T. Jacobs | Zendy; David J. Kissick | Zendy; Thora R. Maltais | Zendy; Hartmut G. Hedderich | Zendy; Patricia A. Bishop | Zendy; Garth J. Simpson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Kinetic Trapping of Metastable Amino Acid Polymorphs

Author(s) -

Azhad U. Chowdhury,

Christopher M. Dettmar,

Shane Z. Sullivan,

Shijie Zhang,

Kevin T. Jacobs,

David J. Kissick,

Thora R. Maltais,

Hartmut G. Hedderich,

Patricia A. Bishop,

Garth J. Simpson

Publication year - 2014

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja410293p

Subject(s) - metastability , chemistry , crystallization , crystallography , polymorphism (computer science) , crystal (programming language) , kinetic energy , chemical physics , second harmonic generation , evaporation , synchrotron , organic chemistry , thermodynamics , optics , laser , biochemistry , physics , quantum mechanics , computer science , genotype , gene , programming language

Second harmonic generation (SHG) microscopy measurements indicate that inkjet-printed racemic solutions of amino acids can produce nanocrystals trapped in metastable polymorph forms upon rapid solvent evaporation. Polymorphism impacts the composition, distribution, and physico-kinetic properties of organic solids, with energetic arguments favoring the most stable polymorph. In this study, unfavored noncentrosymmetric crystal forms were observed by SHG microscopy. Polarization-dependent SHG measurement and synchrotron X-ray microdiffraction analysis of individual printed drops are consistent with formation of homochiral crystal production. Fundamentally, these results provide evidence supporting the ubiquity of Ostwald's Rule of Stages, describing the hypothesized transitioning of crystals between metastable polymorphic forms in the early stages of crystal formation. Practically, the presence of homochiral metastable forms has implications on chiral resolution and on solid form preparations relying on rapid solvent evaporation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research