Polymerization-Induced Self-Assembly of Galactose-Functionalized Biocompatible Diblock Copolymers for Intracellular Delivery | Zendy

Vincent Ladmiral | Zendy; Mona Semsarilar | Zendy; Irene Cantón | Zendy; Steven P. Armes | Zendy

Open Access

Polymerization-Induced Self-Assembly of Galactose-Functionalized Biocompatible Diblock Copolymers for Intracellular Delivery

Author(s) -

Vincent Ladmiral,

Mona Semsarilar,

Irene Cantón,

Steven P. Armes

Publication year - 2013

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja407033x

Subject(s) - chemistry , polymerization , polymersome , copolymer , drug delivery , micelle , biocompatible material , chain transfer , raft , nanotechnology , atom transfer radical polymerization , self assembly , polymer , reversible addition−fragmentation chain transfer polymerization , vesicle , radical polymerization , polymer chemistry , biophysics , aqueous solution , amphiphile , organic chemistry , materials science , membrane , biochemistry , medicine , biomedical engineering , biology

Recent advances in polymer science are enabling substantial progress in nanobiotechnology, particularly in the design of new tools for enhanced understanding of cell biology and for smart drug delivery formulations. Herein, a range of novel galactosylated diblock copolymer nano-objects is prepared directly in concentrated aqueous solution via reversible addition-fragmentation chain transfer polymerization using polymerization-induced self-assembly. The resulting nanospheres, worm-like micelles, or vesicles interact in vitro with galectins as judged by a turbidity assay. In addition, galactosylated vesicles are highly biocompatible and allow intracellular delivery of an encapsulated molecular cargo.

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