Open AccessTotal Synthesis of (±)-Maoecrystal V
Author(s) -
Feng Peng,
Samuel J. Danishefsky
Publication year - 2012
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja309905j
Subject(s) - chemistry , intramolecular force , ring (chemistry) , total synthesis , stereochemistry , combinatorial chemistry , organic chemistry
The total synthesis of racemic maoecrystal V has been accomplished. Key steps include an intramolecular Diels-Alder cyclization to rapidly construct the core system from simple starting materials and the creation of the A-C ring trans-fusion through intramolecular delivery of a hydrogen to the hindered β-face of the ring system.
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