Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery | Zendy

Rong Tong | Zendy; Houman D. Hemmati | Zendy; Róbert Langer | Zendy; Daniel S. Kohane | Zendy

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Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

Author(s) -

Rong Tong,

Houman D. Hemmati,

Róbert Langer,

Daniel S. Kohane

Publication year - 2012

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja211888a

Subject(s) - chemistry , photoisomerization , penetration (warfare) , drug delivery , nanoparticle , biophysics , dispersity , spiropyran , nanotechnology , photochemistry , photochromism , organic chemistry , isomerization , catalysis , materials science , operations research , engineering , biology

We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.

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