Boronate-Mediated Biologic Delivery | Zendy

Gregory A. Ellis | Zendy; Michael J. Palte | Zendy; Ronald T. Raines | Zendy

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Boronate-Mediated Biologic Delivery

Author(s) -

Gregory A. Ellis,

Michael J. Palte,

Ronald T. Raines

Publication year - 2012

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja210719s

Subject(s) - chemistry , macromolecule , cytosol , boronic acid , delivery system , biochemistry , drug delivery , combinatorial chemistry , organic chemistry , enzyme , pharmacology , medicine

Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.

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