A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids | Zendy

Jin Lü | Zendy; Alan J. Stewart | Zendy; Darrell Sleep | Zendy; Peter J. Sadler | Zendy; Teresa J. T. Pinheiro | Zendy; Claudia A. Blindauer | Zendy

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A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids

Author(s) -

Jin Lü,

Alan J. Stewart,

Darrell Sleep,

Peter J. Sadler,

Teresa J. T. Pinheiro,

Claudia A. Blindauer

Publication year - 2012

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja210496n

Subject(s) - chemistry , isothermal titration calorimetry , zinc , albumin , fatty acid , titration , genetic algorithm , biochemistry , mechanism (biology) , serum albumin , amino acid , biophysics , organic chemistry , philosophy , epistemology , evolutionary biology , biology

Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.

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