A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis | Zendy

Yu He | Zendy; David R. Liu | Zendy

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A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis

Author(s) -

Yu He,

David R. Liu

Publication year - 2011

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja201361t

Subject(s) - chemistry , yield (engineering) , dna , combinatorial chemistry , sequence (biology) , displacement (psychology) , dna sequencing , translation (biology) , dna synthesis , computational biology , selection (genetic algorithm) , stereochemistry , algorithm , biological system , biochemistry , gene , computer science , artificial intelligence , psychology , materials science , biology , messenger rna , metallurgy , psychotherapist

We developed a sequential strand-displacement strategy for multistep DNA-templated synthesis (DTS) and used it to mediate an efficient six-step DTS that proceeded in 35% overall yield (83% average yield per step). The efficiency of this approach and the fact that the final product remains linked to a DNA sequence that fully encodes its reaction history suggests its utility for the translation of DNA sequences into high-complexity synthetic libraries suitable for in vitro selection.

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