Open AccessDetermining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms
Author(s) -
Christian Ebner,
Constanze A. Müller,
Christian Märkert,
Andreas Pfaltz
Publication year - 2011
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/ja111700e
Subject(s) - chemistry , catalysis , enantioselective synthesis , organic chemistry , combinatorial chemistry
The enantioselectivity of a chiral catalyst can be determined from its racemic form by mass spectrometric screening of a nonequal mixture of two mass-labeled quasienantiomeric substrates. The presented method opens up new possibilities for evaluating catalyst structures that are not readily available in enantiomerically pure form.
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