Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery System Compatible with Organic Solvents | Zendy

Mary M. Rozenman | Zendy; Matthew W. Kanan | Zendy; David R. Liu | Zendy

Open Access

Development and Initial Application of a Hybridization-Independent, DNA-Encoded Reaction Discovery System Compatible with Organic Solvents

Author(s) -

Mary M. Rozenman,

Matthew W. Kanan,

David R. Liu

Publication year - 2007

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja074155j

Subject(s) - chemistry , dna , markovnikov's rule , combinatorial chemistry , substrate (aquarium) , reaction conditions , dna–dna hybridization , nanotechnology , organic chemistry , biochemistry , regioselectivity , catalysis , oceanography , materials science , geology

We have developed and applied an approach to reaction discovery that takes advantage of DNA encoding, DNA-programmed assembly of substrate pairs, in vitro selection, and PCR amplification, yet does not require reaction conditions that support DNA hybridization. This system allows the simultaneous evaluation of >200 potential bond-forming combinations of substrates in a single experiment and can be applied in a range of solvent and temperature conditions. In an initial application, we applied this system to explore Au(III)-mediated chemistry and uncovered a simple, mild method for the selective Markovnikov-type hydroarylation of vinyl arenes and trisubstituted olefins with indoles.

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