Array-Based Sensing of Proteins Using Conjugated Polymers | Zendy

Oscar R. Miranda | Zendy; ChangCheng You | Zendy; Ronnie L. Phillips | Zendy; IkBum Kim | Zendy; P. S. Ghosh | Zendy; Uwe H. F. Bunz | Zendy; Vincent M. Rotello | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Array-Based Sensing of Proteins Using Conjugated Polymers

Author(s) -

Oscar R. Miranda,

ChangCheng You,

Ronnie L. Phillips,

IkBum Kim,

P. S. Ghosh,

Uwe H. F. Bunz,

Vincent M. Rotello

Publication year - 2007

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja0737927

Subject(s) - chemistry , analyte , conjugated system , polymer , fluorescence , linear discriminant analysis , biological system , biophysics , chromatography , organic chemistry , artificial intelligence , physics , quantum mechanics , computer science , biology

A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research