Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles | Zendy

Yannick Fillon | Zendy; Ayush Verma | Zendy; P. S. Ghosh | Zendy; Dawn Ernenwein | Zendy; Vincent M. Rotello | Zendy; Jean Chmielewski | Zendy

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Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles

Author(s) -

Yannick Fillon,

Ayush Verma,

P. S. Ghosh,

Dawn Ernenwein,

Vincent M. Rotello,

Jean Chmielewski

Publication year - 2007

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja070301+

Subject(s) - chemistry , catalysis , ligation , colloidal gold , peptide , nanoparticle , combinatorial chemistry , nanotechnology , organic chemistry , biochemistry , microbiology and biotechnology , materials science , biology

Trimethylammonium functionalized gold nanoparticles are demonstrated as templates for the assembly of peptide fragments and their subsequently promoted ligation. This system displays the use of organically tailored nanoparticles as effective supramolecular reagents for catalyzing bond-forming reactions and may also serve as a model for prebiotic conditions where charged surfaces may have promoted the polymerization of the early biopolymers.

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