A Red Cy3-Based Biarsenical Fluorescent Probe Targeted to a Complementary Binding Peptide | Zendy

Haishi Cao | Zendy; Yijia Xiong | Zendy; Ting Wang | Zendy; Baowei Chen | Zendy; Thomas C. Squier | Zendy; M. Uljana Mayer | Zendy

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A Red Cy3-Based Biarsenical Fluorescent Probe Targeted to a Complementary Binding Peptide

Author(s) -

Haishi Cao,

Yijia Xiong,

Ting Wang,

Baowei Chen,

Thomas C. Squier,

M. Uljana Mayer

Publication year - 2007

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja070003c

Subject(s) - chemistry , fluorescence , peptide , förster resonance energy transfer , quantum yield , absorbance , combinatorial chemistry , biophysics , chromatography , biochemistry , physics , quantum mechanics , biology

We have synthesized a red biarsenical fluorescent probe, AsCy3, with good photostability, low pH sensitivity, high absorbance, and good quantum yield. It is directed specifically to a small tetracysteine peptide binding motif, Cy3TAG (CysCysLysAlaGluAlaAlaCysCys), in the presence of other tetracysteine tags. This new probe provides a FRET partner to biarsenical dye FlAsH, making this discovery an important step toward a whole toolkit of colored probes directed to different small peptide motifs.

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