Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity | Zendy

Masakazu Fujio | Zendy; Douglass Wu | Zendy; Raquel GarcíaNavarro | Zendy; David D. Ho | Zendy; Moriya Tsuji | Zendy; ChiHuey Wong | Zendy

Open Access

Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity

Author(s) -

Masakazu Fujio,

Douglass Wu,

Raquel GarcíaNavarro,

David D. Ho,

Moriya Tsuji,

ChiHuey Wong

Publication year - 2006

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja062740z

Subject(s) - cd1d , chemistry , glycolipid , adjuvant , secretion , alpha (finance) , immunosuppression , biochemistry , stereochemistry , natural killer t cell , microbiology and biotechnology , immunology , in vitro , cytotoxic t cell , biology , medicine , construct validity , nursing , patient satisfaction

Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

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