A Genetically Encoded Fluorescent Amino Acid | Zendy

Jiangyun Wang | Zendy; Jianming Xie | Zendy; Peter G. Schultz | Zendy

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A Genetically Encoded Fluorescent Amino Acid

Author(s) -

Jiangyun Wang,

Jianming Xie,

Peter G. Schultz

Publication year - 2006

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja062666k

Subject(s) - chemistry , fluorescence , amino acid , quantum yield , green fluorescent protein , polarity (international relations) , fluorescent protein , biochemistry , yield (engineering) , biophysics , gene , physics , quantum mechanics , biology , cell , materials science , metallurgy

The fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine 1 has been genetically encoded in E. coli in response to the amber TAG codon. Because of its high fluorescence quantum yield, relatively large Stoke's shift, and sensitivity to both pH and polarity, this amino acid should provide a useful probe of protein localization and trafficking, protein conformation changes, and protein-protein interactions.

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