Multi-Frequency High-Field EPR Study of Iron Centers in Malarial Pigments | Zendy

Andrzej Sienkiewicz | Zendy; J. Krzystek | Zendy; Bertrand Vileno | Zendy; Guillaume Chatain | Zendy; Aaron J. Kosar | Zendy; D. Scott Bohle | Zendy; L. Forró | Zendy

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Multi-Frequency High-Field EPR Study of Iron Centers in Malarial Pigments

Author(s) -

Andrzej Sienkiewicz,

J. Krzystek,

Bertrand Vileno,

Guillaume Chatain,

Aaron J. Kosar,

D. Scott Bohle,

L. Forró

Publication year - 2006

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja058420h

Subject(s) - hemozoin , electron paramagnetic resonance , chemistry , pigment , protoporphyrin ix , microwave , photochemistry , nuclear magnetic resonance , crystallography , heme , organic chemistry , physics , photodynamic therapy , quantum mechanics , enzyme

The multi-frequency high-field electron paramagnetic resonance (HFEPR) was used to study the magnetic properties of malarial pigment hemozoin and its synthetic analogue, beta-hematin. (FeIII-protoporphyrin-IX)2 dimers containing five-coordinate high-spin FeIII, S = 5/2, are the building blocks of these pigments. The fit of EPR spectra that were acquired in an unprecedented wide range of microwave frequencies of 34 and 94 GHz for hemozoin and 27-500 GHz for beta-hematin yielded a complete set of intrinsic spin Hamiltonian parameters: D = +5.85(1) cm-1, E = 0, g perpendicular = 1.95(1), g parallel = 2.00(1). These results point to the existence of largely axial symmetry of the iron environment in the bulk phase of hemozoin and beta-hematin.

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