Reversal of Enantioselectivity in the Asymmetric Rhodium- versus Iridium-Catalyzed Hydroboration of Meso Substrates | Zendy

Alejandro PérezLuna | Zendy; Martine Bonin | Zendy; Laurent Micouin | Zendy; HenriPhilippe Husson | Zendy

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Reversal of Enantioselectivity in the Asymmetric Rhodium- versus Iridium-Catalyzed Hydroboration of Meso Substrates

Author(s) -

Alejandro PérezLuna,

Martine Bonin,

Laurent Micouin,

HenriPhilippe Husson

Publication year - 2002

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja026714m

Subject(s) - hydroboration , chemistry , iridium , desymmetrization , rhodium , enantioselective synthesis , enantiomer , catalysis , bicyclic molecule , asymmetric hydrogenation , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry

The Ir-catalyzed asymmetric hydroboration of bicyclic hydrazines with ee and chemical yields up to 64% is reported. The switch from rhodium to iridium leads systematically to opposite enantiomers in this desymmetrization reaction.

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