Ultrafast excited-state processes in the antiviral agent hypericin | Zendy

Feng Gai | Zendy; Michael J. Fehr | Zendy; Jacob W. Petrich | Zendy

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Ultrafast excited-state processes in the antiviral agent hypericin

Author(s) -

Feng Gai,

Michael J. Fehr,

Jacob W. Petrich

Publication year - 1993

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/ja00061a069

Subject(s) - citation , altmetrics , icon , computer science , social media , information retrieval , world wide web , programming language

Hypericin (Figure 1) has been shown by Lavieet al. toinactivate mature and properly assembled retroviruses, notably human immunodeficiency virus (HIV).' Recently Kraus, Carpenter, and co-workers demonstrated the antiretroviral activity of hypericin against equine infectious anemia virus (EIAV), a lentivirus closely related to HIV, and have determined that light is required for activity.2 The requirement of light leads to the fundamental questions, what is the mechanism of action of hypericin and what is the role of light?

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