Synthesis, Characterization, and X-ray Attenuation Properties of Ultrasmall BiOI Nanoparticles: Toward Renal Clearable Particulate CT Contrast Agents | Zendy

Murthi S. Kandanapitiye | Zendy; Min Gao | Zendy; Joseph Molter | Zendy; Chris A. Flask | Zendy; Songping D. Huang | Zendy

Open Access

Synthesis, Characterization, and X-ray Attenuation Properties of Ultrasmall BiOI Nanoparticles: Toward Renal Clearable Particulate CT Contrast Agents

Author(s) -

Murthi S. Kandanapitiye,

Min Gao,

Joseph Molter,

Chris A. Flask,

Songping D. Huang

Publication year - 2014

Publication title -

inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.348

H-Index - 233

eISSN - 1520-510X

pISSN - 0020-1669

DOI - 10.1021/ic5011709

Subject(s) - chemistry , nanoparticle , characterization (materials science) , iodine , attenuation , x ray , bismuth , nanotechnology , chemical engineering , materials science , organic chemistry , optics , physics , engineering

A unique decelerated hydrolytic procedure is developed and reported here for the preparation of ultrasmall nanoparticles (NPs) of PVP-coated BiOI with a narrow size distribution, i.e., 2.8 ± 0.5 nm. The crystal structure of this compound is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, and potential use of the PVP-coated ultrasmall BiOI NPs as a CT contrast agent are investigated. Because of the combined X-ray attenuation effect of bismuth and iodine, such NPs exhibit a CT value that is among the best of those of the inorganic nanoparticle-based CT contrast agents reported in the literature.

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