Open AccessEnantioselective Cascade Cyclization/Protodemetalation of Polyenes with N3Pt2+ Catalysts
Author(s) -
Nguyen Thi Hoang Ha,
Michel R. Gagné
Publication year - 2014
Publication title -
acs catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.898
H-Index - 198
ISSN - 2155-5435
DOI - 10.1021/cs401190c
Subject(s) - enantioselective synthesis , cycloisomerization , catalysis , chemistry , electrophile , ligand (biochemistry) , cascade , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor , chromatography
The combination of the N-based pincer ligand PyBOX with Pt 2+ leads to new catalysts for the enantioselective cycloisomerization of dienyl- and trienyl-ols. The mechanistic combination of electrophilic cyclization followed by rapid protodemetalation is surprising and leads to a powerful construct for developing new reactions.
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