Interpreting Chemical Neurotransmission in Vivo: Techniques, Time Scales, and Theories | Zendy

Martin Sarter | Zendy; Youngsoo Kim | Zendy

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Interpreting Chemical Neurotransmission in Vivo: Techniques, Time Scales, and Theories

Author(s) -

Martin Sarter,

Youngsoo Kim

Publication year - 2014

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/cn500319m

Subject(s) - neurotransmitter , neuroscience , neurotransmission , acetylcholine , cholinergic , neurotransmitter systems , neurotransmitter agents , in vivo , neurotransmitter receptor , extracellular , cholinergic system , biology , computer science , central nervous system , pharmacology , receptor , microbiology and biotechnology , dopamine , biochemistry

Monitoring neurotransmitter levels is a major research strategy for determining the functions of neuronal systems, specifically the ascending neuromodulator systems. In this Viewpoint, we consider the impact of different methods for recording extracellular neurotransmitter levels in vivo on theories concerning the signaling mode(s) and functions of these neuronal systems. As exemplified by evidence from experiments using different methods to measure acetylcholine (ACh) signaling, both neuromodulatory and deterministic functions have been attributed to cholinergic activity. Technical and experimental advances now allow determination of the validity of such dual-signaling theories.

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