Open AccessGold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging
Author(s) -
Prashant Sharma,
Scott C. Brown,
Niclas E. Bengtsson,
Qizhi Zhang,
Glenn A. Walter,
Stephen R. Grobmyer,
Swadeshmukul Santra,
Huabei Jiang,
Edward W. Scott,
Brij M. Moudgil
Publication year - 2008
Publication title -
chemistry of materials
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.741
H-Index - 375
eISSN - 1520-5002
pISSN - 0897-4756
DOI - 10.1021/cm801020s
Subject(s) - materials science , gadolinium , nanoparticle , colloidal gold , magnetic resonance imaging , nanotechnology , photoacoustic imaging in biomedicine , nuclear magnetic resonance , biomedical engineering , optics , radiology , medicine , physics , metallurgy
Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions. Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.