Viruslike Nanoparticles with Maghemite Cores Allow for Enhanced MRI Contrast Agents | Zendy

Andrey Malyutin | Zendy; Rosemary Easterday | Zendy; Yaroslav Lozovyy | Zendy; Alessandro Spilotros | Zendy; Hu Cheng | Zendy; Olivia R. Sanchez-Felix | Zendy; Barry Stein | Zendy; David Morgan | Zendy; Dmitri I. Svergun | Zendy; Bogdan Dragnea | Zendy; Lyudmila M. Bronstein | Zendy

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Viruslike Nanoparticles with Maghemite Cores Allow for Enhanced MRI Contrast Agents

Author(s) -

Andrey Malyutin,

Rosemary Easterday,

Yaroslav Lozovyy,

Alessandro Spilotros,

Hu Cheng,

Olivia R. Sanchez-Felix,

Barry Stein,

David Morgan,

Dmitri I. Svergun,

Bogdan Dragnea,

Lyudmila M. Bronstein

Publication year - 2014

Publication title -

chemistry of materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.741

H-Index - 375

eISSN - 1520-5002

pISSN - 0897-4756

DOI - 10.1021/cm504029j

Subject(s) - maghemite , nanoparticle , colloidal gold , brome mosaic virus , hepatitis a virus , capsid , chemistry , iron oxide , iron oxide nanoparticles , feline calicivirus , nanotechnology , virus , coating , materials science , biophysics , virology , biology , rna , biochemistry , organic chemistry , rna dependent rna polymerase , gene

Here, for the first time, we demonstrate formation of virus-like nanoparticles (VNPs) utilizing gold-coated iron oxide nanoparticles as cores and capsid protein of brome mosaic virus (BMV) or hepatitis B virus (HBV) as shells. Further, utilizing cryo-electron microscopy and single particle methods, we are able to show that the BMV coat on VNPs assembles into a structure very close to that of a native virion. This is a consequence of an optimal iron oxide NP size (∼11 nm) fitting the virus cavity and an ultrathin gold layer on the maghemite cores, which allows for utilization of SH-(CH2)11-(CH2-CH2-O)4-OCH2-COOH as capping molecules to provide sufficient stability, charge density, and small form factor. MRI studies show unique relaxivity ratios that diminish only slightly with gold coating. A virus protein coating of a magnetic core mimicking the wild-type virus makes these VNPs a versatile platform for biomedical applications

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