Well-Ordered Mesoporous Silica Nanoparticles as Cell Markers | Zendy

YuShen Lin | Zendy; ChihPin Tsai | Zendy; Hsing-Yi Huang | Zendy; ChiehTi Kuo | Zendy; Yann Hung | Zendy; Dongming Huang | Zendy; YaoChang Chen | Zendy; ChungYuan Mou | Zendy

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Well-Ordered Mesoporous Silica Nanoparticles as Cell Markers

Author(s) -

YuShen Lin,

ChihPin Tsai,

Hsing-Yi Huang,

ChiehTi Kuo,

Yann Hung,

Dongming Huang,

YaoChang Chen,

ChungYuan Mou

Publication year - 2005

Publication title -

chemistry of materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.741

H-Index - 375

eISSN - 1520-5002

pISSN - 0897-4756

DOI - 10.1021/cm051014c

Subject(s) - mesoporous silica , nanoparticle , mesoporous material , materials science , nanotechnology , fluorescein , silicon dioxide , chemical engineering , biophysics , chemistry , fluorescence , catalysis , organic chemistry , engineering , physics , quantum mechanics , metallurgy , biology

[[abstract]]Well-dispersed dye functionalized hexagonal crystal-like mesoporous silica nanoparticles were synthesized with high yield under dilute conditions, and the cell labeling capability was analyzed. The fluorescein isothiocyanate (FITC) functionalized mesoporous silica nanoparticles with sizes around 110 nm were demonstrated to be internalized into 3T3-L1 fibroblast cells and to accumulate in cytoplasm. The mesoporous silica nanoparticles appeared to have no apparent cytotoxic effects on the fibroblast cells. It was shown that the cellular internalization appears to be generic for various cells

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