Wrestling with Native Chemical Ligation | Zendy

Hagan Bayley | Zendy; Stephen Cheley | Zendy; Leon Harrington | Zendy; Ruhma Syeda | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Wrestling with Native Chemical Ligation

Author(s) -

Hagan Bayley,

Stephen Cheley,

Leon Harrington,

Ruhma Syeda

Publication year - 2009

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb900304p

Subject(s) - semisynthesis , native chemical ligation , ligation , chemistry , chemical ligation , potassium channel , amino acid , membrane , template , biochemistry , computational biology , biophysics , biology , nanotechnology , chemical synthesis , microbiology and biotechnology , in vitro , materials science

An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research