Open AccessFluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays
Author(s) -
Sung Jin Park,
Jung Won Sung,
Injae Shin
Publication year - 2009
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb9002078
Subject(s) - glycomics , glycan , dna microarray , computational biology , glycome , microscale chemistry , microarray , biology , chemistry , biochemistry , glycoprotein , gene , gene expression , mathematics education , mathematics
Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces. An article in this issue of ACS Chemical Biology describes the microscale preparation of fluorescently labeled reactive glycans in a cyclic form of the reducing sugar, from natural sources, that can be utilized directly to create natural glycan microarrays for use in functional glycomics.