Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays | Zendy

Sungjin Park | Zendy; Jung-Won Sung | Zendy; Injae Shin | Zendy

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Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays

Author(s) -

Sungjin Park,

Jung-Won Sung,

Injae Shin

Publication year - 2009

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb9002078

Subject(s) - glycomics , glycan , dna microarray , computational biology , glycome , microscale chemistry , microarray , biology , chemistry , biochemistry , glycoprotein , gene , gene expression , mathematics education , mathematics

Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces. An article in this issue of ACS Chemical Biology describes the microscale preparation of fluorescently labeled reactive glycans in a cyclic form of the reducing sugar, from natural sources, that can be utilized directly to create natural glycan microarrays for use in functional glycomics.

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