Inhibitor of Apoptosis (IAP) Proteins: Novel Insights into the Cancer-Relevant Targets for Cell Death Induction | Zendy

Simone Fulda | Zendy

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Inhibitor of Apoptosis (IAP) Proteins: Novel Insights into the Cancer-Relevant Targets for Cell Death Induction

Author(s) -

Simone Fulda

Publication year - 2009

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb900150g

Subject(s) - xiap , inhibitor of apoptosis , apoptosis , programmed cell death , cancer research , cancer cell , cancer , inhibitor of apoptosis domain , biology , chemistry , microbiology and biotechnology , caspase , biochemistry , genetics

Inhibitor of apoptosis (IAP) proteins are expressed at high levels in various cancers and block apoptosis at a key node. Therefore, there is currently much interest in IAP antagonists as cancer therapeutics. Structure-based development of selective IAP inhibitors now provides, for the first time, evidence that simultaneous inhibition of the c-IAP proteins and XIAP is necessary for efficient induction of cancer cell death by IAP antagonists.

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