Open AccessSmaller Is Better for Antibiotic Discovery
Author(s) -
Grover L. Waldrop
Publication year - 2009
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb900122j
Subject(s) - drug discovery , antibiotics , biotin , virtual screening , pyruvate carboxylase , computational biology , chemistry , biology , biochemistry , enzyme
A recent study demonstrates the use of fragment-based drug discovery and virtual screening to develop inhibitors of biotin carboxylase that exhibit antibacterial activity. The work not only further validates biotin carboxylase as a target for antibiotic research but also provides a framework for using fragment-based drug discovery in antibiotic development.
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