Peptide Inhibitors of HIV-1 Egress | Zendy

Abdül Waheed | Zendy; Eric O. Freed | Zendy

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Peptide Inhibitors of HIV-1 Egress

Author(s) -

Abdül Waheed,

Eric O. Freed

Publication year - 2008

Publication title -

acs chemical biology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb800296j

Subject(s) - tsg101 , escrt , endosome , microbiology and biotechnology , peptide , human immunodeficiency virus (hiv) , group specific antigen , chemistry , plasma protein binding , biology , computational biology , biophysics , biochemistry , virology , intracellular , microvesicles , gene , microrna

HIV-1 release requires a direct interaction between the p6 domain of the Gag protein and Tsg101, a component of the cellular endosomal sorting complex required for transport I (ESCRT-I). Disruption of the binding between Gag and Tsg101 is highly detrimental to particle release, making this viral-host cell interaction a potential target for the development of novel anti-HIV-1 agents. An article in this issue reports on the application of a bacterial reverse two-hybrid strategy to identify a cyclic peptide that disrupts Gag-Tsg101 binding and suppresses HIV-1 particle release.

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