Open AccessAllostery: DNA Does It, Too
Author(s) -
Jonathan B. Chaires
Publication year - 2008
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb800070s
Subject(s) - allosteric regulation , dna , allosteric enzyme , transcription (linguistics) , computational biology , protein–dna interaction , biophysics , function (biology) , chemistry , transcription factor , biology , microbiology and biotechnology , dna binding protein , biochemistry , gene , enzyme , linguistics , philosophy
Allostery is a central concept for understanding protein function and regulation. It is less well appreciated that DNA is allosteric, too, and that DNA conformational changes can by coupled to protein binding interactions on the DNA lattice. Allosteric DNA interactions are emerging as important features in the assembly of the molecular machines that regulate transcription.