Open AccessEster Bonds in Prodrugs
Author(s) -
Luke D. Lavis
Publication year - 2008
Publication title -
acs chemical biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb800065s
Subject(s) - prodrug , context (archaeology) , chemistry , molecule , stereochemistry , biochemistry , combinatorial chemistry , organic chemistry , biology , paleontology
A recent study challenges the oft-held notion that ester bonds in prodrug molecules are cleaved rapidly and completely inside cells by endogenous, nonspecific esterases. Structure-activity relationship studies on acylated sugars reveal that regioisomeric compounds display disparate biological activity, suggesting that ester bonds can persist in a cellular context.
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