Unnatural Translation Initiation | Zendy

John W. Tomsho | Zendy; Stephen J. Benkovic | Zendy

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Unnatural Translation Initiation

Author(s) -

John W. Tomsho,

Stephen J. Benkovic

Publication year - 2008

Publication title -

acs chemical biology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb8000233

Subject(s) - transfer rna , methionine , translation (biology) , amino acid , protein biosynthesis , chemistry , biochemistry , rna , peptide , biology , messenger rna , gene

Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids. In addition, it was determined that this system could accommodate these non-methionine amino acids containing various N-alpha-acyl groups, many of which are useful for post-translational modification such as peptide cyclization.

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