Signaling by Committee: Receptor Clusters Determine Pathways of Cellular Activation | Zendy

Christopher W. Cairo | Zendy

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Signaling by Committee: Receptor Clusters Determine Pathways of Cellular Activation

Author(s) -

Christopher W. Cairo

Publication year - 2007

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb700214x

Subject(s) - receptor , signal transduction , microbiology and biotechnology , mechanism (biology) , cell signaling , biology , cluster analysis , computational biology , chemistry , biochemistry , computer science , philosophy , epistemology , machine learning

Receptor clustering is a common signaling mechanism for cell surface receptors. Exogenous ligands such as antibodies or synthetic analogues can be used to artificially induce clustering. New studies using defined synthetic ligands suggest that the spatial organization of these clusters attenuates signaling in one pathway but has no effect in another.

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