Open AccessA Triple Play for Thyroid Hormone
Author(s) -
Ross Weatherman
Publication year - 2007
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb700104v
Subject(s) - thyroid , hormone , thyroid hormones , intracellular , reuptake , monoamine neurotransmitter , endocrinology , biology , central nervous system , neuroscience , medicine , microbiology and biotechnology , receptor , serotonin
A class of thyroid hormone metabolites has dramatic physiological effects on metabolism and heart rate by still-unknown mechanisms of action. A recent study has discovered that thyronamines can inhibit neuronal reuptake of neurotransmitters and prevent the intracellular transport of monoamines for release. This discovery presents a third signaling pathway for thyroid hormone, expands the role that thyroid plays in the central nervous system, and suggests mechanisms of action for the effects of thyronamine-derived neuromodulators.