A Triple Play for Thyroid Hormone | Zendy

Ross Weatherman | Zendy

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A Triple Play for Thyroid Hormone

Author(s) -

Ross Weatherman

Publication year - 2007

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb700104v

Subject(s) - thyroid , hormone , thyroid hormones , intracellular , reuptake , monoamine neurotransmitter , endocrinology , biology , central nervous system , neuroscience , medicine , microbiology and biotechnology , receptor , serotonin

A class of thyroid hormone metabolites has dramatic physiological effects on metabolism and heart rate by still-unknown mechanisms of action. A recent study has discovered that thyronamines can inhibit neuronal reuptake of neurotransmitters and prevent the intracellular transport of monoamines for release. This discovery presents a third signaling pathway for thyroid hormone, expands the role that thyroid plays in the central nervous system, and suggests mechanisms of action for the effects of thyronamine-derived neuromodulators.

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