Open AccessRegulation and Specificity of S-Nitrosylation and Denitrosylation
Author(s) -
Steven R. Tannenbaum,
Forest M. White
Publication year - 2006
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb600439h
Subject(s) - s nitrosylation , nitric oxide , signal transduction , nitrosylation , microbiology and biotechnology , smooth muscle , neurotransmission , chemistry , biology , neuroscience , biochemistry , cysteine , receptor , endocrinology , enzyme
Signal transduction from nitric oxide (NO) is important in physiological processes such as smooth muscle relaxation and neurotransmission. NO signaling occurs through a variety of mechanisms, including S-nitrosylation (SNO) of sulfhydryl groups in protein. A paper in this issue of the journal dissects the regulatory system involved in SNO of caspase-3 and highlights the need for more direct investigations of the complex biological regulation by NO signaling.