Open AccessCholesterol, It’s Not Just For Heart Disease Anymore
Author(s) -
Amy Kerzmann,
Andrew L. Feig
Publication year - 2006
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb600133b
Subject(s) - clostridium difficile , disease , microbiology and biotechnology , toxin , diarrhea , antibiotics , cholesterol , medicine , clostridium difficile toxin a , intensive care medicine , biology
Recent studies have shown that cholesterol plays a significant role in the ability of Toxin A from Clostridium difficile to enter eukaryotic cells. The translocation process is one of three major steps during intoxication that could be targeted for intervention against the severe antibiotic-associated diarrhea caused by C. difficile.
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