Open AccessThe Stochastic Nature of Gene Expression Revealed at the Single-Molecule Level
Author(s) -
Xin Chen,
Paul S. Cremer
Publication year - 2006
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb600129z
Subject(s) - computational biology , gene , gene expression , biology , in vivo , microbiology and biotechnology , genetics
Two recent papers have monitored the real-time synthesis of proteins in vivo at the single-molecule level. The work was done by two separate methods: fluorescent protein labeling and enzymatic amplification. Statistical analysis of the data reveals the inherent stochastic nature of gene expression.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom