Open AccessTargeting Translation in Hypoxic Tumors
Author(s) -
David Ron,
Alan G. Hinnebusch
Publication year - 2006
Publication title -
acs chemical biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb600125y
Subject(s) - translation (biology) , biology , hypoxia (environmental) , microbiology and biotechnology , computational biology , chemistry , biochemistry , messenger rna , gene , organic chemistry , oxygen
Recent insight into how mammalian cells adapt their translational machinery to hypoxic conditions raises the possibility of targeting components of the regulatory networks involved to selectively inhibit metabolically compromised tumor cells and possibly manipulate a broad range of other physiological processes.