Open AccessRaising Enzymes from the Dead and the Secrets They Can Tell
Author(s) -
Michael A. Marletta
Publication year - 2006
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb600110g
Subject(s) - proto oncogene tyrosine protein kinase src , function (biology) , raising (metalworking) , computational biology , sorting , sequence (biology) , biology , signal transduction , microbiology and biotechnology , computer science , genetics , engineering , mechanical engineering , programming language
The complexity of partners and reaction sequence has made the deciphering eukaryotic signaling pathways particularly difficult. Various approaches have yielded important results. A recent paper reports on an advance that uses chemical rescue of inactive mutant of Src. The rescue was done in cells, and the results obtained showing new aspects of Src function point the way toward a general use of this chemical tool in the sorting out of complex biological processes.