MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria | Zendy

Mateo I. Sánchez | Zendy; José Martı́nez-Costas | Zendy; José L. Mascareñas | Zendy; M. Eugenio Vázquez | Zendy

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MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria

Author(s) -

Mateo I. Sánchez,

José Martı́nez-Costas,

José L. Mascareñas,

M. Eugenio Vázquez

Publication year - 2014

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb500552f

Subject(s) - mitochondrion , photobleaching , streptavidin , chemistry , derivative (finance) , biotin , fluorescence , biophysics , biochemistry , combinatorial chemistry , biology , physics , quantum mechanics , financial economics , economics

We report the discovery of a fluorogenic dye, N(1),N(3)-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria.

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