Open AccessOrganophosphorus Flame Retardants Inhibit Specific Liver Carboxylesterases and Cause Serum Hypertriglyceridemia
Author(s) -
Patrick J. Morris,
Daniel Medina-Cleghorn,
Ann Heslin,
Sarah M. King,
Joseph Orr,
Melinda M. Mulvihill,
Ronald M. Krauss,
Daniel K. Nomura
Publication year - 2014
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/cb500014r
Subject(s) - hypertriglyceridemia , dyslipidemia , lipid metabolism , chemistry , metabolomics , biology , biochemistry , bioinformatics , endocrinology , cholesterol , triglyceride , obesity
Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver carboxylesterases (Ces) and cause altered hepatic lipid metabolism. Ablation of the OPFR target Ces1g has been previously linked to dyslipidemia in mice. Consistent with OPFR inhibition of Ces1g, we also observe OPFR-induced serum hypertriglyceridemia in mice. Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals.
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